• The lieutenant governor assumes the powers of governor if the governor is unable to discharge his duties.  If the disability is temporary (such as illness or absence from the state), the lieutenant governor serves as acting governor during the period of disability.  If the disability is permanent (such as death or removal from office), the lieutenant governor becomes governor.
• The lieutenant governor serves as the ex officio president of the Missouri Senate.  He casts a vote only in case of a tie vote by the elected senators.  Senate rules severely restrict the presiding powers of the lieutenant governor.
• The lieutenant governor is also official elderly advocate for the state as well as a member of the SenioRX Commission.

The current lieutenant governor is Peter Kinder. He is currently running for reelection to a second term.

• The Secretary of State prepares all statewide ballots and certifies statewide ballot measures that are proposed by the General Assembly.
  
• The office also has the responsibility of the office to canvass, certify and publish election results.
  
• The Secretary of State regulates securities within the state and is responsible for enforcement of the state's securities laws.  The office also operates a division for maintaining corporation registrations and other corporate filings.
  
• The Business Division of the Secretary of State commissions notaries public and registers all Missouri businesses.
  
• The Secretary of State's office maintains various official records for the state, including the Missouri Register and Missouri Code of State Regulations.  He or she also maintains the state's official archives.
  
• He or She publishes the "Official Manual" of Missouri.
  
• The State Library is part of the Secretary of State's office.

The current secretary of state is Robin Carnahan, who seeking reelection to a second term.

• The State Treasurer is the state's chief financial officer.  The office manages the state's revenues, directs the state's banking services and manages the state's investment portfolio.  A major portion of the State Treasurer's responsibility is to invest unused state funds into interest-bearing account.  However, some government monies such as various government employee retirement funds and the higher education institution fund are handled separately.
  
• He or she serves on the management boards of several public entities, such as MOST, the College Savings Plan. 
  
• The State Treasurer operates a program that tries to locate of owners over unclaimed assets that have been turned over to the state by banks, businesses, insurance companies and government agencies.  Unclaimed property mostly consists of cash from bank accounts, stocks, bonds and contents of safety deposit boxes. It does not handle real property such as land, houses, cars and boats.

The current State Treasurer is Sarah Steelman, who has served one term as treasurer.  No person can serve as State Treasurer for more than two terms. 

• The attorney general is the state's "chief legal officer."  When legally challenged, he defends the constitutionality of state statutes and actions of state officials.  He also can bring suits or defend the state in suits involving the state's interests, rights and claims. However, many agencies in the state hire their own lawyers to also represent their agency interests. 
• The attorney general represents the state in every felony criminal case appeal and death sentence reviews by the state Supreme Court. 
• He or she has the responsibility to institute legal action to remove from some government officials from elective office
• The Attorney General has authority to seek the ouster from various offices any public official holding office illegally (such as a felony conviction).  This ouster power does not, however, include offices covered by the the state's impeachment provisions in which the Missouri House institutes ouster proceedings.
• The attorney general operates consumer-protection services including administration of the state's "No Call List" dealing with telemarketers, enforcement of Missouri's Consumer Protection Act and enforcement of anti-trust laws.   The attorney general also serves as the state's chief prosecutor for securities fraud. 

The current attorney general is Democratic gubernatorial candidate Jay Nixon, who finishing his fourth term.